The tirzepatide prescribing information recommends discontinuing at least 1 month before planned conception. However, tirzepatide has a half-life of about 5 days, meaning it takes roughly 25-30 days (5 half-lives) to be substantially cleared from your body. Some providers recommend waiting 2 months to be conservative. Semaglutide has a longer half-life (~7 days) and recommends a 2-month washout. Discuss the specific timeline with your healthcare provider based on your situation.