Yes, many people combine IF with GLP-1 agonists without problems. Since the medication already reduces appetite, you may naturally drift toward fewer, larger meals. The main concern is making sure you eat enough—GLP-1s plus strict fasting can lead to inadequate protein and calorie intake, risking muscle loss and nutrient deficiencies. If you practice IF, focus eating windows on nutrient-dense, protein-rich meals. Don't use fasting as a way to accelerate already-rapid weight loss.