Yes. Rapid weight loss from any cause—not just GLP-1 medications—increases gallstone risk. When you lose fat quickly, the liver secretes extra cholesterol into bile, which can crystallize into stones. GLP-1 agonists also slow gallbladder emptying, compounding the risk. Symptoms include sudden right-upper-abdominal pain, especially after fatty meals. Staying hydrated, not skipping meals entirely, and maintaining some dietary fat intake may help reduce risk. If you develop symptoms, see a doctor.