There's a theoretical risk, and pancreatitis is listed as a warning on GLP-1 prescribing information. In clinical trials, the incidence was very low and not clearly higher than placebo in most studies. However, if you have a history of pancreatitis, most doctors recommend avoiding GLP-1 agonists. Watch for severe, persistent abdominal pain radiating to the back, especially with vomiting—this warrants immediate medical attention and stopping the medication.