Yes. Both semaglutide and tirzepatide are not recommended during pregnancy. Animal studies showed embryotoxic effects at high doses. The prescribing information for semaglutide recommends stopping at least 2 months before planned conception; for tirzepatide, the recommendation is at least 1 month (though some providers suggest longer due to its 5-day half-life). If you discover you're pregnant while on a GLP-1 agonist, stop immediately and contact your doctor—but don't panic, as animal studies used higher doses than human therapeutic doses.