If you miss your scheduled dose by a day or two, take it as soon as you remember. If it's been more than half your dosing interval (e.g., more than 3-4 days late on a weekly injection), skip the missed dose and take your next one on the regular schedule. Don't double up to compensate. Missing a single dose won't undo your progress—the long half-lives of tirzepatide (~5 days) and semaglutide (~7 days) mean you'll still have active medication in your system for days after a missed dose.