No significant direct drug interactions are known between GLP-1 agonists and most psychiatric medications. However, the delayed gastric emptying may slow absorption of oral psychiatric medications. Also, rapid weight loss and dietary changes can affect how your body metabolizes some drugs. If you're on psychiatric medication, let your prescriber know you're starting a GLP-1 agonist so they can monitor for any changes in efficacy or side effects. Don't adjust psychiatric medications on your own.