Yes, and you probably should. GLP-1 agonists reduce appetite significantly, making it harder to get adequate nutrition from food alone. A basic multivitamin is a good baseline. Magnesium and electrolytes are especially important if you're experiencing GI side effects (vomiting, diarrhea). B12 supplementation is worth considering if you're eating much less. There are no known interactions between common supplements and GLP-1 peptides. Take supplements with food when possible to improve absorption and reduce nausea.