Some people report mood changes, including increased anxiety, depression, or emotional flatness. The FDA and EMA have investigated reports of suicidal ideation but have not established a causal link as of early 2025. Rapid weight loss itself can affect mood and body image. If you notice significant mood changes after starting a GLP-1 agonist, talk to your doctor. These experiences are worth monitoring but shouldn't be dismissed as imaginary—your mental health matters alongside your physical health.