Studies show that most people regain a significant portion of lost weight after stopping GLP-1 medications—typically about two-thirds within a year in clinical trials. Your appetite returns to pre-treatment levels because the medication was managing it, not curing the underlying biology. However, people who maintain exercise habits, high protein intake, and behavioral changes during treatment tend to keep more weight off. Some people stay on a low maintenance dose long-term. This is an important factor in your overall plan.